HORDB

ID: hor004365
Uniprot ID: P01289
Protein name: Neurokinin A
Gene name: TAC1
Organism: Bos taurus (Bovine)
Family: Tachykinin family
Source: animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Bos (genus), Bovinae (subfamily), Bovidae (family), Pecora (infraorder), Ruminantia (suborder), Artiodactyla (order), Laurasiatheria (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0031835 substance P receptor binding
GO BP: GO:0006954 inflammatory response; GO:0007204 positive regulation of cytosolic calcium ion concentration; GO:0007217 tachykinin receptor signaling pathway; GO:0007218 neuropeptide signaling pathway; GO:0007268 chemical synaptic transmission; GO:0019233 sensory perception of pain; GO:0048265 response to pain
GO CC: GO:0005576 extracellular region; GO:0005615 extracellular space; GO:0030424 axon; GO:0043025 neuronal cell body; GO:0045202 synapse

Sequence: HKTDSFVGLM
Length: 10
Propeptide: MKILVAVAVIFFISTQLSAEEIGANDDFNYWSDWSDSDQIKEEMPEPFEHLLQRIARRPKPQQFFGLMGKRDADSSIEKQVALLKALYGHGQLSHKRHKTDSFVGLMGKRALNSVAYERSVMQDYERRRK
Signal peptide: MKILVAVAVIFFISTQLSA
Modification: T10 Methionine amide
Glycosylation: NA
Mutagenesis: NA

Function: Excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles
Mechanism: NA
Cross BBB: NA
Target: TACR1, TACR2
Target Unid: F1MIX5, P05363
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

AF-P07808-F1.pdb

hor004365_AF2.pdb

hor004365_ESM.pdb

Mass:	129503	Formula:	C50H79N13O15S
Absent amino acids:	ACEINPQRWY	Common amino acids:	DFGHKLMSTV
pI:	7.55	Basic residues:	2
Polar residues:	3	Hydrophobic residues:	3
Hydrophobicity:	2	Boman Index:	-967
Half-Life:	3.5 hour	Half-Life Yeast:	10 min
Half-Life E.Coli:	>10 hour	Aliphatic Index	68
Instability Index:	4345	Extinction Coefficient cystines:	0
Absorbance 280nm:	0